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Zafirlukast (Accolate): A New Treatment for Capsular Contracture

S. Larry Schlesinger MD, Richard Ellenbogen MD, Michael N. Desvigne MD, Steven Svehlak MD, Robert Heck MD
DOI: http://dx.doi.org/10.1067/maj.2002.126753 329-336 First published online: 1 July 2002

Abstract

Background Capsular contracture after breast augmentation or reconstructive breast surgery is a difficult problem. Previous studies have suggested that alteration of the inflammatory response could have a role in reducing the incidence of capsular contracture.

Objective We report a series of patients with Baker class III or IV capsular contracture who underwent treatment with zafirlukast.

Methods Patients received a regimen of zafirlukast 20 mg by mouth 2 times daily for 3 months.

Results In many cases, dramatic softening of the breast capsule was evident after 1 to 3 months of treatment.

Conclusions Zafirlukast appears to effectively soften early capsular contracture and may prevent the formation of capsular contracture in those patients at risk.

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