OUP user menu

Clinical Applications of Mesenchymal Stem Cells in Soft Tissue Augmentation

Summer E. Hanson, Karol A. Gutowski, Peiman Hematti
DOI: http://dx.doi.org/10.1177/1090820X10386364 838-842 First published online: 1 November 2010

Abstract

Based on a variety of preclinical studies showing that mesenchymal stem cells (MSC) play a significant role in tissue repair and homeostasis, MSC have rapidly moved into a phase of clinical trials investigating their efficacy as a cell-based therapeutic modality for a diverse group of applications. An emerging body of evidence shows that in addition to being a progenitor cell population with self-renewing and multipotent differentiation capabilities, MSC have unique immunomodulatory properties, making them even more attractive for regenerative medicine. Emerging discoveries in stem cell biology have revealed a multitude of mechanisms through which MSC could potentially augment the current techniques in aesthetic surgery. In this article, the authors review the clinical advances in cell-based therapies relevant to aesthetic surgery, including tissue augmentation, rejuvenation, and regeneration.

Keywords
  • mesenchymal stem cells
  • fat grafting
  • cosmetic augmentation
  • immune modulation
View Full Text

Log in through your institution